The Hetao Institute for Mathematics and Interdisciplinary Studies (Shenzhen) is a research institution initiated by internationally renowned mathematician and Fields Medal laureate Professor Shing-Tung Yau. It was formally established on 25 April 2025 within the Shenzhen Park of the Hetao Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone. The institute focuses on fundamental mathematics, applied mathematics, and interdisciplinary research between mathematics and artificial intelligence. It adopts a research paradigm comprising "25% fundamental mathematics, 50% applied mathematics, and 25% interdisciplinary research and technology transfer". Professor Shing-Tung Yau serves as Chairman of the Board, with Professor Shing-Tung Yau Jr. as Executive Vice President. Leveraging the geographical advantages of the Hetao Shenzhen-Hong Kong Cooperation Zone, the institute has signed cooperation agreements with institutions including The Chinese University of Hong Kong, Shenzhen. Its inaugural cohort of 17 researchers includes internationally renowned mathematicians such as Shing-Tung Yau and Chengdong Yau. Its core objective is to integrate mathematical theory with practical applications, providing technical support such as algorithm optimisation for fields including artificial intelligence and low-altitude economy, thereby serving the development of Shenzhen as a centre for industrial science and technology innovation.